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Corticosteroid injection reduces short-term (less than six weeks) symptoms from lateral epicondylitis, but physical therapy is superior to steroid injection after six weeks.16 A report from the U.S.A. of corticosteroid therapy for lateral epicondylitis concluded that it is not superior to corticosteroids and should not be recommended.17 Corticosteroid use has been associated with both serious and benign adverse reactions. Hepatotoxicity and liver damage have been reported with corticosteroids.18 Liver failure has been reported as the outcome with the use of corticosteroids.19 Corticosteroids are associated with an increased incidence of nephrotoxicity and/or acute hepatic failure. The incidence of acute hepatic failure is similar to the general population. It occurs in less than 1% of patients treated with corticosteroids.1,2 Corticosteroids appear to have only minor hepatic toxicity, and the incidence of hepatic failure is not greater than 10%.16,20,21,22 Chronic adverse effects of corticosteroids appear to be rare, although some are serious and require medical attention. The incidence rates of adverse reactions with the use of corticosteroids vary, but in most cases are minor enough to be avoided. It is estimated only 6-24% of patients will experience any problems with corticosteroids, compared to 25-50% who will have an adverse reaction. The incidence rates of adverse reactions are very similar if different corticosteroid treatments are used. Pregnancy: Adverse pregnancy and fetal complications may result from use of corticosteroids. Adverse pregnancy following the administration of corticosteroids is minimal and occurs in 5-7% of the cases of corticosteroid therapy. The risk of harm (birth defects) from the use of corticosteroids during pregnancy is approximately five times higher than the risk if they are not used.23 Postpartum: The incidence of puerperal morbidity or mortality is increased.24-27 Adverse Events and Laboratory Tests: Common adverse results with corticosteroids include acute severe myocardial infarction, and severe vasculitis.14-16,20,21 Post-surgical complications such as pulmonary hypertension or cardiovascular mortality occur in between 3% and 8% of patients.14,18 The rate of adverse events during clinical trials for corticosteroids exceeded that of the other drugs studied for the treatment of acute myocardial infarction. Related Article:
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